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Some animal studies suggest GLP-1 receptors exist in brain regions involved in stress response, including the hypothalamus and amygdala, raising theoretical possibilities for neuroendocrine modulation

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Cardiovasc Res 36:276281 Masaki I, Yonemitsu Y, Yamashita A, Sata S, Tanii M, Komori K, Nakagawa K, Hou X, Nagai Y, Hasegawa M et al (2002) Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2

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Because rapamycin, which extends mouse lifespan 31 , can reverse age-related diastolic dysfunction and restore a more youthful metabolome in the aged myocardium 32 , we next evaluated metabolomic changes in Young, Old Con, and Old mAb female-treated hearts

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